Publicaciones

Rebecca C. Coll, Kate Schroder, Pablo Pelegrín Highlights The nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is a key mediator of pathological inflammation in many diseases. There are several drug-like small molecules under clinical development as novel therapeutics targeting the NLRP3 inflammasome. Pyroptosis is a unique approach to suppress chronic […]

Malvina Pizzuto, Pablo Pelegrin, Jean-Marie Ruysschaert Abstract The inflammatory response is a complex regulated effector mechanism of the innate immune system that is initiated after tissue injury or infection. The NLRP3 inflammasome is an important initiator of inflammation by regulating the activation of caspase-1, the maturation of pro-inflammatory cytokines and the induction of pyroptotic cell

Alejandro Peñin-Franch, José Antonio García-Vidal, Carlos Manuel Martínez, Pilar Escolar-Reina, Rosa M Martínez-Ojeda, Ana I Gómez, Juan M Bueno, Francisco Minaya-Muñoz, Fermín Valera-Garrido, Francesc Medina-Mirapeix, Pablo Pelegrín Abstract The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic

Creative commons, artículo original en: ¿Se podría considerar la diabetes una enfermedad inflamatoria? (theconversation.com). La inflamación es una respuesta coordinada por las células de nuestro sistema inmunitario ante un daño en el organismo o ante la presencia de algún agente infeccioso. Esta puede ser localizada en una zona del cuerpo y se caracteriza por producir

Artículo original en Hallan un nuevo inductor del proceso inflamatorio en enfermedades raras, cardiovasculares, degenerativas y metabólicas | La Verdad Investigadores de la UMU y el IMIB identifican una nueva región en la proteína NLRP3, importante para su activación que podría ser una diana terapéutica frente a patologías como la gota, la diabetes o el

Original document in Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation (science.org) Ana Tapia-Abellán, Diego Angosto-Bazarra, Cristina Alarcón-Vilamaría C. Baños, Va Hafner-Bratkovič, Baldomero Oliva And Pablo Pelegrín, Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation. SCIENCE ADVANCES • 15

Creative Commons, original document in P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis | Nature Communications Martínez-García, J., Martínez-Banaclocha, H., Angosto-Bazarra, D. et al. P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis. Nat Commun 10, 2711 (2019). https://doi.org/10.1038/s41467-019-10626-x Abstract Sepsis is characterized by a systemic inflammatory response followed